Short Communication Identification of neuropeptide Y-like conopeptides from the venom of Conus betulinus
نویسندگان
چکیده
XuechenWu1, Xiaoxia Shao1, Zhan-Yun Guo1*, and Cheng-Wu Chi1,2* Institute of Protein Research, College of Life Sciences and Technology, Tongji University, Shanghai 200092, China State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, Shanghai 200031, China *Correspondence address. Tel: þ86-21-65988634; Fax: þ86-21-65988403; E-mail: [email protected] (Z.-Y.G.). Tel: þ86-21-54921165; E-mail: [email protected] (C.-W.C.)
منابع مشابه
Identification of neuropeptide Y-like conopeptides from the venom of Conus betulinus.
Neuropeptide Y (NPY) is a ubiquitous endocrine neuropeptide found in vertebrate and invertebrate. In our present work, two NPY-like exocrine conopeptides (designated as cono-NPYs) were first identified in the venom of cone snails. Both cono-NPYs showed sequence characteristics of invertebrate NPYs, suggesting that some exocrine venom peptides are probably evolved from the preexisting endocrine ...
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BACKGROUND The venom of predatory marine cone snails mainly contains a diverse array of unique bioactive peptides commonly referred to as conopeptides or conotoxins. These peptides have proven to be valuable pharmacological probes and potential drugs because of their high specificity and affinity to important ion channels, receptors and transporters of the nervous system. Most previous studies ...
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